Protein Details: Voltage-gated Potassium channel-interacting protein 4

Protein ID

ICDB_Pro_1097

Protein Name

Voltage-gated Potassium channel-interacting protein 4

Gene Name

Kcnip4; Calp; Kchip4

Organism

Mus musculus (Mouse)

Length

250 amino acids

AlphaFoldDB

AF-Q6PHZ8-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels; such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane; gating characteristics; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner

Sequence

MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

PDB Structures

3DD4

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

133;135;137;144;169;171;173;175;180;217;219;221;228

Disease

Location

Expressed in brain. Highly expressed by neurons in layers II-IV of cortex and in hippocampus; thalamus and the Purkinje cell layer of the cerebellum.

DOI ID

10.1074/jbc.m200897200; 10.1073/pnas.022509299; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/j.molbrainres.2004.06.024; 10.4161/chan.3.4.9553; 10.1016/j.cell.2010.12.001; 10.1523/jneurosci.2487-10.2010; 10.1016/j.mcn.2009.12.005; 10.1074/jbc.m807704200

RefSeq

NP_001186171.1 [Q6PHZ8-1]; NP_001186172.1 [Q6PHZ8-2]; NP_084541.3 [Q6PHZ8-4]